Title |
Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance
|
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Published in |
Frontiers in Pharmacology, September 2016
|
DOI | 10.3389/fphar.2016.00354 |
Pubmed ID | |
Authors |
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa |
Abstract |
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal transducer and activator of transcription 5 (STAT5) in neuronal cells. Flurbiprofen reversed glucose deprivation-mediated attenuation of STAT3, but not STAT5 activation, in leptin-treated cells. Glucose deprivation increased C/EBP-homologous protein and glucose regulated protein 78 induction, indicating the activation of unfolded protein responses (UPR). Flurbiprofen did not affect the glucose deprivation-induced activation of UPR, but did attenuate the glucose deprivation-mediated induction of AMP-activated protein kinase phosphorylation. Flurbiprofen may ameliorate glucose deprivation-induced leptin resistance in neuronal cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Lecturer > Senior Lecturer | 2 | 25% |
Student > Ph. D. Student | 2 | 25% |
Student > Master | 1 | 13% |
Researcher | 1 | 13% |
Professor > Associate Professor | 1 | 13% |
Other | 0 | 0% |
Unknown | 1 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 38% |
Environmental Science | 1 | 13% |
Chemistry | 1 | 13% |
Neuroscience | 1 | 13% |
Unknown | 2 | 25% |