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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
|
|---|---|
| Published in |
Frontiers in Pharmacology, September 2016
|
| DOI | 10.3389/fphar.2016.00359 |
| Pubmed ID | |
| Authors |
José A. S. Crippa, Ana C. S. Crippa, Jaime E. C. Hallak, Rocio Martín-Santos, Antonio W. Zuardi |
| Abstract |
Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Δ9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Δ9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 18% |
| Argentina | 3 | 11% |
| Denmark | 2 | 7% |
| Sweden | 2 | 7% |
| United Kingdom | 2 | 7% |
| Spain | 1 | 4% |
| Mexico | 1 | 4% |
| Hungary | 1 | 4% |
| Ireland | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 8 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 75% |
| Scientists | 5 | 18% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 177 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 13% |
| Student > Bachelor | 24 | 13% |
| Student > Master | 20 | 11% |
| Student > Ph. D. Student | 19 | 11% |
| Student > Postgraduate | 13 | 7% |
| Other | 31 | 17% |
| Unknown | 47 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 19% |
| Neuroscience | 18 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 9% |
| Psychology | 10 | 6% |
| Chemistry | 9 | 5% |
| Other | 36 | 20% |
| Unknown | 56 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2022.
All research outputs
#1,550,368
of 25,026,088 outputs
Outputs from Frontiers in Pharmacology
#599
of 19,180 outputs
Outputs of similar age
#27,390
of 329,839 outputs
Outputs of similar age from Frontiers in Pharmacology
#12
of 160 outputs
Altmetric has tracked 25,026,088 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,180 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,839 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.