Title |
Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions
|
---|---|
Published in |
Frontiers in Pharmacology, October 2016
|
DOI | 10.3389/fphar.2016.00396 |
Pubmed ID | |
Authors |
Ruwen Böhm, Ingolf Cascorbi |
Abstract |
Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B reactions. We present the classifications of ADR, discuss genetic influences and focus on delayed-onset hypersensitivity reactions, i.e., drug-induced liver injury, drug-induced agranulocytosis, and severe cutaneous ADR. A guidance how to read and interpret the contingency table is provided as well as an algorithm whether and how a test for a pharmacogenetic biomarker should be conducted. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 63% |
Argentina | 1 | 13% |
Spain | 1 | 13% |
Switzerland | 1 | 13% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 17% |
Student > Ph. D. Student | 8 | 10% |
Student > Master | 8 | 10% |
Student > Bachelor | 6 | 8% |
Student > Postgraduate | 5 | 6% |
Other | 16 | 21% |
Unknown | 22 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 19% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 12% |
Agricultural and Biological Sciences | 6 | 8% |
Computer Science | 2 | 3% |
Other | 11 | 14% |
Unknown | 24 | 31% |