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Mendeley readers
Attention Score in Context
| Title |
Genetic and Pharmacological Inhibition of p38α Improves Locomotor Recovery after Spinal Cord Injury
|
|---|---|
| Published in |
Frontiers in Pharmacology, February 2017
|
| DOI | 10.3389/fphar.2017.00072 |
| Pubmed ID | |
| Authors |
Hiroki Umezawa, Yusuke Naito, Kensuke Tanaka, Kento Yoshioka, Kenichi Suzuki, Tatsuhiko Sudo, Masahiko Hagihara, Masahiko Hatano, Koichiro Tatsumi, Yoshitoshi Kasuya |
| Abstract |
One of the mitogen-activated protein kinases, p38α plays a crucial role in various inflammatory diseases and apoptosis of various types of cells. In this study, we investigated the pathophysiological roles of p38α in spinal cord injury (SCI), using a mouse model. Lateral hemisection at T9 of the SC was performed in wild type (WT) and p38α(+/-) mice (p38α(-/-) showed embryonic lethality). p38α(+/-) mice showed a better functional recovery from SCI-associated paralyzed hindlimbs compared to WT mice at 7 days post-injury (dpi), which remained until 28 dpi (an end time point of monitoring the behavior). In histopathological analysis at 28 dpi, there was more axonal regeneration with remyelination on the caudal side of the lesion epicenter in p38α(+/-) mice than in WT mice. At 7 dpi, infiltration of inflammatory cells into the lesion and expression of cytokines in the lesion were reduced in p38α(+/-) mice compared with WT mice. At the same time point, the number of apoptotic oligodendrocytes in the white matter at the caudal boarder of the lesion of p38α(+/-) mice was lower than that of WT mice. At 14 dpi, more neural and oligodendrocyte precursor cells in the gray matter and white matter, respectively, were observed around the lesion epicenter of p38α(+/-) mice compared with the case of WT mice. At the same time point, astrocytic scar formation was less apparent in p38α(+/-) than in WT mice, while compaction of inflammatory immune cells associated with the wound contraction was more apparent in p38α(+/-) than in WT mice. Furthermore, we verified the effectiveness of oral administration of SB239063, a p38α inhibitor on the hindlimb locomotor recovery after SCI. These results suggest that p38α deeply contributes to the pathogenesis of SCI and that inhibition of p38α is a beneficial strategy to recovery from SCI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 20% |
| Student > Master | 2 | 13% |
| Researcher | 2 | 13% |
| Lecturer | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Other | 4 | 27% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 3 | 20% |
| Neuroscience | 3 | 20% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Psychology | 1 | 7% |
| Veterinary Science and Veterinary Medicine | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2017.
All research outputs
#20,403,545
of 22,953,506 outputs
Outputs from Frontiers in Pharmacology
#10,143
of 16,230 outputs
Outputs of similar age
#269,902
of 309,434 outputs
Outputs of similar age from Frontiers in Pharmacology
#120
of 193 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,230 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.