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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review
|
|---|---|
| Published in |
Frontiers in Pharmacology, February 2017
|
| DOI | 10.3389/fphar.2017.00096 |
| Pubmed ID | |
| Authors |
Hazrulrizawati A. Hamid, Aizi N. M. Ramli, Mashitah M. Yusoff |
| Abstract |
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L. Harman, harmol, harmine, harmalol and harmaline are indole alkaloids isolated from P. incarnata, while mitragynine is isolated from M. speciosa. The structure of isolated compounds from P. methysticum G. Forst and V. officinalis L. contains an indole moiety. The indole moiety is related to the neurotransmitter serotonin which is widely implicated for brain function and cognition as the endogenous receptor agonist. An imbalance in serotonin levels may influence mood in a way that leads to depression. The moiety is present in a number of antidepressants already on the market. Hence, the objective of this review is to discuss bioactive compounds containing the indole moiety from plants that can serve as potent antidepressants. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 281 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 15% |
| Student > Bachelor | 35 | 12% |
| Student > Master | 34 | 12% |
| Researcher | 17 | 6% |
| Other | 12 | 4% |
| Other | 30 | 11% |
| Unknown | 113 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 57 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 29 | 10% |
| Agricultural and Biological Sciences | 23 | 8% |
| Biochemistry, Genetics and Molecular Biology | 17 | 6% |
| Medicine and Dentistry | 11 | 4% |
| Other | 27 | 10% |
| Unknown | 118 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2023.
All research outputs
#6,347,652
of 23,427,600 outputs
Outputs from Frontiers in Pharmacology
#2,610
of 16,957 outputs
Outputs of similar age
#101,679
of 311,909 outputs
Outputs of similar age from Frontiers in Pharmacology
#39
of 195 outputs
Altmetric has tracked 23,427,600 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 16,957 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 195 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.