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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets
|
|---|---|
| Published in |
Frontiers in Pharmacology, May 2017
|
| DOI | 10.3389/fphar.2017.00280 |
| Pubmed ID | |
| Authors |
Víctor López, Birgitte Nielsen, Maite Solas, Maria J. Ramírez, Anna K. Jäger |
| Abstract |
Lavender essential oil is traditionally used and approved by the European Medicines Agency (EMA) as herbal medicine to relieve stress and anxiety. Some animal and clinical studies reveal positive results in models of anxiety and depression although very little research has been done on molecular mechanisms. Our work consisted of evaluating the effects of lavender (Lavandula angustifolia) essential oil on central nervous system well-established targets, such as MAO-A, SERT, GABAAand NMDA receptors as well as in vitro models of neurotoxicity. The results showed that lavender essential oil and its main components exert affinity for the glutamate NMDA-receptor in a dose-dependent manner with an IC50 value of 0.04 μl/mL for lavender oil. In addition, lavender and linalool were also able to bind the serotonin transporter (SERT) whereas they did not show affinity for GABAA-benzodiazepine receptor. In three different models of neurotoxicity, lavender did not enhance the neurotoxic insult and improved viability of SH-SY5Y cells treated with hydrogen peroxide. According to our data, the anxiolytic and antidepressant-like effects attributed to lavender may be due to an antagonism on the NMDA-receptor and inhibition of SERT. This study suggests that lavender essential oil may exert pharmacological properties via modulating the NMDA receptor, the SERT as well as neurotoxicity induced by hydrogen peroxide. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 26% |
| Japan | 2 | 9% |
| Australia | 1 | 4% |
| Belgium | 1 | 4% |
| India | 1 | 4% |
| United Kingdom | 1 | 4% |
| South Africa | 1 | 4% |
| Canada | 1 | 4% |
| Switzerland | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 96% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 431 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 431 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 71 | 16% |
| Researcher | 34 | 8% |
| Student > Master | 32 | 7% |
| Student > Ph. D. Student | 28 | 6% |
| Student > Doctoral Student | 18 | 4% |
| Other | 70 | 16% |
| Unknown | 178 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 49 | 11% |
| Agricultural and Biological Sciences | 35 | 8% |
| Medicine and Dentistry | 33 | 8% |
| Nursing and Health Professions | 31 | 7% |
| Biochemistry, Genetics and Molecular Biology | 23 | 5% |
| Other | 69 | 16% |
| Unknown | 191 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2023.
All research outputs
#566,357
of 25,808,886 outputs
Outputs from Frontiers in Pharmacology
#212
of 20,019 outputs
Outputs of similar age
#11,459
of 327,435 outputs
Outputs of similar age from Frontiers in Pharmacology
#12
of 247 outputs
Altmetric has tracked 25,808,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 20,019 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,435 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 247 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.