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Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

Overview of attention for article published in Frontiers in Pharmacology, May 2017
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Title
Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
Published in
Frontiers in Pharmacology, May 2017
DOI 10.3389/fphar.2017.00289
Pubmed ID
Authors

Jialiang Gao, Guang Chen, Haoqiang He, Chao Liu, Xingjiang Xiong, Jun Li, Jie Wang

Abstract

Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 12%
Student > Postgraduate 4 10%
Student > Ph. D. Student 4 10%
Lecturer 3 7%
Researcher 3 7%
Other 7 17%
Unknown 16 38%
Readers by discipline Count As %
Medicine and Dentistry 8 19%
Pharmacology, Toxicology and Pharmaceutical Science 5 12%
Biochemistry, Genetics and Molecular Biology 4 10%
Nursing and Health Professions 4 10%
Agricultural and Biological Sciences 1 2%
Other 2 5%
Unknown 18 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2017.
All research outputs
#20,422,914
of 22,974,684 outputs
Outputs from Frontiers in Pharmacology
#10,159
of 16,256 outputs
Outputs of similar age
#272,938
of 313,690 outputs
Outputs of similar age from Frontiers in Pharmacology
#156
of 244 outputs
Altmetric has tracked 22,974,684 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,256 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,690 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 244 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.