Title |
Exosomes: A Novel Strategy for Treatment and Prevention of Diseases
|
---|---|
Published in |
Frontiers in Pharmacology, June 2017
|
DOI | 10.3389/fphar.2017.00300 |
Pubmed ID | |
Authors |
Jiaqi Wang, Xiaoyan Sun, Jiayu Zhao, Yang Yang, Xueting Cai, Jianguang Xu, Peng Cao |
Abstract |
An "exosome" is a nanoscale membrane vesicle derived from cell endocytosis that functions as an important intercellular communication mediator regulating the exchange of proteins and genetic materials between donor and surrounding cells. Exosomes secreted by normal and cancer cells participate in tumor initiation, progression, invasion, and metastasis. Furthermore, immune cells and cancer cells exert a two-way bidirectional regulatory effect on tumor immunity by exchanging exosomes. Current studies on exosomes have further expanded their known functions in physiological and pathological processes. The purpose of this review is to describe their discovery and biological functions in the context of their enormous potential in the clinical diagnosis, prevention, and treatment of cancer as well as bacterial and viral infectious diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Slovenia | 1 | 17% |
United Kingdom | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 164 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 28 | 17% |
Researcher | 24 | 15% |
Student > Bachelor | 22 | 13% |
Student > Ph. D. Student | 21 | 13% |
Student > Doctoral Student | 10 | 6% |
Other | 29 | 18% |
Unknown | 30 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 27% |
Agricultural and Biological Sciences | 25 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
Medicine and Dentistry | 10 | 6% |
Immunology and Microbiology | 7 | 4% |
Other | 31 | 19% |
Unknown | 37 | 23% |