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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line
|
|---|---|
| Published in |
Frontiers in Pharmacology, June 2017
|
| DOI | 10.3389/fphar.2017.00336 |
| Pubmed ID | |
| Authors |
R. Dhanya, A. D. Arya, P. Nisha, P. Jayamurthy |
| Abstract |
Herein we investigated the molecular mechanism of action of the citrus flavonoid, quercetin in skeletal muscle cells (L6 myotubes). Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK. An increase in the cellular AMP to ATP ratio on pretreatment may account for AMPK activation which was coupled with a transient change in mitochondrial membrane potential. In addition, quercetin triggered a rise in intracellular calcium suggesting that calcium-calmodulin mediated protein kinase (CaMKK) may also be involved. Quercetin shared a similar mechanism with the well-known drug metformin, highlighting it as a promising compound for the management of type 2 diabetes. The AMPK signaling pathway could contribute to correction of insulin resistance through bypassing the insulin-regulated system for GLUT4 translocation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 130 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 12% |
| Student > Bachelor | 14 | 11% |
| Student > Master | 13 | 10% |
| Student > Ph. D. Student | 12 | 9% |
| Lecturer | 7 | 5% |
| Other | 15 | 12% |
| Unknown | 54 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 9% |
| Agricultural and Biological Sciences | 9 | 7% |
| Medicine and Dentistry | 9 | 7% |
| Nursing and Health Professions | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 61 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2023.
All research outputs
#2,516,255
of 25,611,630 outputs
Outputs from Frontiers in Pharmacology
#1,069
of 19,975 outputs
Outputs of similar age
#45,846
of 332,077 outputs
Outputs of similar age from Frontiers in Pharmacology
#28
of 258 outputs
Altmetric has tracked 25,611,630 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,975 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 258 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.