Title |
Antimicrobial Activity and Resistance: Influencing Factors
|
---|---|
Published in |
Frontiers in Pharmacology, June 2017
|
DOI | 10.3389/fphar.2017.00364 |
Pubmed ID | |
Authors |
Jun Li, Shuyu Xie, Saeed Ahmed, Funan Wang, Yufeng Gu, Chaonan Zhang, Ximan Chai, Yalan Wu, Jinxia Cai, Guyue Cheng |
Abstract |
Rational use of antibiotic is the key approach to improve the antibiotic performance and tackling of the antimicrobial resistance. The efficacy of antimicrobials are influenced by many factors: (1) bacterial status (susceptibility and resistance, tolerance, persistence, biofilm) and inoculum size; (2) antimicrobial concentrations [mutant selection window (MSW) and sub-inhibitory concentration]; (3) host factors (serum effect and impact on gut micro-biota). Additional understandings regarding the linkage between antimicrobial usages, bacterial status and host response offers us new insights and encourage the struggle for the designing of antimicrobial treatment regimens that reaching better clinical outcome and minimizing the emergence of resistance at the same time. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | <1% |
Unknown | 550 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 94 | 17% |
Student > Ph. D. Student | 51 | 9% |
Student > Master | 49 | 9% |
Researcher | 43 | 8% |
Lecturer | 24 | 4% |
Other | 85 | 15% |
Unknown | 205 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 66 | 12% |
Biochemistry, Genetics and Molecular Biology | 62 | 11% |
Immunology and Microbiology | 45 | 8% |
Medicine and Dentistry | 41 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 27 | 5% |
Other | 87 | 16% |
Unknown | 223 | 40% |