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Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility

Overview of attention for article published in Frontiers in Pharmacology, July 2017
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Title
Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility
Published in
Frontiers in Pharmacology, July 2017
DOI 10.3389/fphar.2017.00450
Pubmed ID
Authors

Jacqueline M. Barker, Kathleen G. Bryant, Jennifer I. Osborne, L. J. Chandler

Abstract

Human alcoholics have been shown to have impaired cognitive control over actions and increased reliance on habitual response strategies. While it is unclear in humans whether these differences predate ethanol exposure or result from chronic drinking, data from animal studies suggest that ethanol acts to promote the development of inflexible behaviors. Here, we investigated how intermittent exposure to high doses of ethanol impacts the ability to flexibly regulate behavior in a habit model. As adolescence, may represent a period of increased drug taking and developmental vulnerability that may impact adult behavior, we compared the effects of high-dose ethanol exposure during adolescence to exposure during adulthood in male and female rats. Our findings indicated that the effects of intermittent, high-dose ethanol exposure on habitual behavior is mediated by age and sex such that ethanol exposure during adolescence promoted the use of habitual response strategies in adult females, but not males, and that the opposite pattern emerged following intermittent, high-dose ethanol exposure in adult rats.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Researcher 6 14%
Student > Master 4 9%
Professor 3 7%
Professor > Associate Professor 3 7%
Other 8 18%
Unknown 12 27%
Readers by discipline Count As %
Neuroscience 15 34%
Agricultural and Biological Sciences 5 11%
Psychology 3 7%
Unspecified 2 5%
Medicine and Dentistry 1 2%
Other 1 2%
Unknown 17 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2017.
All research outputs
#20,433,667
of 22,986,950 outputs
Outputs from Frontiers in Pharmacology
#10,174
of 16,272 outputs
Outputs of similar age
#272,884
of 313,004 outputs
Outputs of similar age from Frontiers in Pharmacology
#159
of 250 outputs
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So far Altmetric has tracked 16,272 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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