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Mendeley readers
Attention Score in Context
| Title |
DAF-16/FOXO Transcription Factor in Aging and Longevity
|
|---|---|
| Published in |
Frontiers in Pharmacology, August 2017
|
| DOI | 10.3389/fphar.2017.00548 |
| Pubmed ID | |
| Authors |
Xiaojuan Sun, Wei-Dong Chen, Yan-Dong Wang |
| Abstract |
Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signaling pathway, TOR signaling, AMPK pathway, JNK pathway and germline signaling have been found to be involved in aging and longevity. And DAF-16/FOXO, as a key transcription factor, could integrate different signals from these pathways to modulate aging, and longevity via shuttling from cytoplasm to nucleus. Hence, understanding how DAF-16/FOXO functions will be pivotal to illustrate the processes of aging and longevity. Here, we summarized how DAF-16/FOXO receives signals from these pathways to affect aging and longevity. We also briefly discussed the transcriptional regulation and posttranslational modifications of DAF-16/FOXO, its co-factors as well as its potential downstream targets participating in lifespan according to the published data in C. elegans and in mammals, and in most cases, we may focus on the studies in C. elegans which has been considered to be a very good animal model for longevity research. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 326 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 326 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 81 | 25% |
| Student > Ph. D. Student | 51 | 16% |
| Student > Master | 34 | 10% |
| Researcher | 18 | 6% |
| Other | 10 | 3% |
| Other | 28 | 9% |
| Unknown | 104 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 115 | 35% |
| Agricultural and Biological Sciences | 40 | 12% |
| Medicine and Dentistry | 12 | 4% |
| Neuroscience | 12 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 28 | 9% |
| Unknown | 114 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2023.
All research outputs
#1,683,498
of 24,205,409 outputs
Outputs from Frontiers in Pharmacology
#627
of 18,078 outputs
Outputs of similar age
#33,680
of 320,995 outputs
Outputs of similar age from Frontiers in Pharmacology
#5
of 250 outputs
Altmetric has tracked 24,205,409 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,078 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 250 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.