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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of Ferroptosis in Cancer Development and Treatment Response
|
|---|---|
| Published in |
Frontiers in Pharmacology, January 2018
|
| DOI | 10.3389/fphar.2017.00992 |
| Pubmed ID | |
| Authors |
Bin Lu, Xiao Bing Chen, Mei Dan Ying, Qiao Jun He, Ji Cao, Bo Yang |
| Abstract |
Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell death, which is a distinct regulated cell death comparing to other cell death. The lethal metabolic imbalance resulted from GSH depletion or inactivation of glutathione peroxidase 4 is the executor of ferroptosis within the cancer cell. Small molecules-induced ferroptosis has a strong inhibition of tumor growth and enhances the sensitivity of chemotherapeutic drugs, especially in the condition of drug resistance. These evidences have highlighted the importance of ferroptosis in cancer therapeutics, but the roles of ferroptosis in tumorigenesis and development remain unclear. This article provides an overview of the mechanisms of ferroptosis, highlights the role of ferroptosis in cancer and discusses strategies for therapeutic modulation. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 8 | 12% |
| India | 3 | 4% |
| United States | 3 | 4% |
| Spain | 2 | 3% |
| South Africa | 2 | 3% |
| Turkey | 2 | 3% |
| Switzerland | 2 | 3% |
| Ecuador | 2 | 3% |
| Venezuela, Bolivarian Republic of | 2 | 3% |
| Other | 19 | 28% |
| Unknown | 24 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 52 | 75% |
| Scientists | 13 | 19% |
| Practitioners (doctors, other healthcare professionals) | 3 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 288 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 15% |
| Student > Master | 39 | 14% |
| Researcher | 35 | 12% |
| Student > Bachelor | 30 | 10% |
| Student > Doctoral Student | 16 | 6% |
| Other | 30 | 10% |
| Unknown | 96 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 78 | 27% |
| Medicine and Dentistry | 25 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 7% |
| Agricultural and Biological Sciences | 18 | 6% |
| Chemistry | 17 | 6% |
| Other | 27 | 9% |
| Unknown | 104 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2022.
All research outputs
#945,727
of 25,759,158 outputs
Outputs from Frontiers in Pharmacology
#356
of 19,997 outputs
Outputs of similar age
#21,628
of 453,469 outputs
Outputs of similar age from Frontiers in Pharmacology
#9
of 254 outputs
Altmetric has tracked 25,759,158 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,997 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 254 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.