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Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis

Overview of attention for article published in Frontiers in Pharmacology, January 2018
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  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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Title
Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis
Published in
Frontiers in Pharmacology, January 2018
DOI 10.3389/fphar.2017.00997
Pubmed ID
Authors

Sang Hyun Lim, Elizabeth-Ann Legere, Jamie Snider, Igor Stagljar

Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resulting from perturbations of this protein interaction network. Studying the collection of CFTR interacting proteins and the differences between the interactomes of mutant and wild type CFTR provides insight into the molecular machinery of the disease and highlights possible therapeutic targets. This mini review focuses on functional genomics and proteomics approaches used for systematic, high-throughput identification of CFTR-interacting proteins to provide comprehensive insight into CFTR regulation and function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Researcher 9 17%
Student > Master 8 15%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 3 6%
Other 5 10%
Unknown 13 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 31%
Agricultural and Biological Sciences 8 15%
Engineering 3 6%
Medicine and Dentistry 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 8%
Unknown 18 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2018.
All research outputs
#14,866,830
of 23,782,909 outputs
Outputs from Frontiers in Pharmacology
#5,049
of 17,443 outputs
Outputs of similar age
#245,529
of 445,585 outputs
Outputs of similar age from Frontiers in Pharmacology
#89
of 272 outputs
Altmetric has tracked 23,782,909 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 17,443 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,585 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.