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Clozapine Use During Pregnancy and Lactation: A Case-Series Report

Overview of attention for article published in Frontiers in Pharmacology, March 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

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6 X users

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Title
Clozapine Use During Pregnancy and Lactation: A Case-Series Report
Published in
Frontiers in Pharmacology, March 2018
DOI 10.3389/fphar.2018.00264
Pubmed ID
Authors

M. Luisa Imaz, Giovanni Oriolo, Mercè Torra, Dolors Soy, Lluïsa García-Esteve, Rocio Martin-Santos

Abstract

The current prescription of clozapine in psychotic women of reproductive age makes it crucial to understand its pharmacokinetics during pregnancy and lactation as well as its risk profile for neonatal outcome. The aim of this case series was to provide new evidence on the pharmacokinetic features of clozapine that determine its passage through the placenta and amniotic fluid, as well as the neonatal clozapine elimination half-life (t1/2). This case series demonstrates for the first time that clozapine might show partial placental passage similar to other atypical antipsychotics. Clozapine levels decreased during the first few days in nursing infants. The half-life of clozapine in neonates was slightly higher than previously estimated. Clozapine use in pregnancy may be associated with diabetes mellitus, especially if there is a family history of this disease. Although no acute toxicological effects were observed in the intrauterine exposed newborn, close follow-up of pregnancy is recommended. However, these results must be taken with caution being a case series with small sample size.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 15%
Student > Bachelor 9 15%
Student > Ph. D. Student 5 8%
Student > Postgraduate 5 8%
Student > Master 5 8%
Other 13 21%
Unknown 15 25%
Readers by discipline Count As %
Medicine and Dentistry 15 25%
Psychology 8 13%
Nursing and Health Professions 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 10 16%
Unknown 17 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2022.
All research outputs
#13,978,726
of 24,900,093 outputs
Outputs from Frontiers in Pharmacology
#4,101
of 19,031 outputs
Outputs of similar age
#160,137
of 335,339 outputs
Outputs of similar age from Frontiers in Pharmacology
#97
of 375 outputs
Altmetric has tracked 24,900,093 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,031 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,339 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 375 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.