Title |
Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review
|
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Published in |
Frontiers in Pharmacology, April 2018
|
DOI | 10.3389/fphar.2018.00428 |
Pubmed ID | |
Authors |
Dongqing Guo, Colin E. Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen |
Abstract |
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 16 | 25% |
Student > Ph. D. Student | 7 | 11% |
Student > Master | 5 | 8% |
Researcher | 4 | 6% |
Other | 2 | 3% |
Other | 1 | 2% |
Unknown | 29 | 45% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 11% |
Chemistry | 6 | 9% |
Agricultural and Biological Sciences | 4 | 6% |
Medicine and Dentistry | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 10 | 16% |
Unknown | 29 | 45% |