Title |
Familial Hypercholesterolemia: New Horizons for Diagnosis and Effective Management
|
---|---|
Published in |
Frontiers in Pharmacology, July 2018
|
DOI | 10.3389/fphar.2018.00707 |
Pubmed ID | |
Authors |
Maria Mytilinaiou, Ioannis Kyrou, Mike Khan, Dimitris K. Grammatopoulos, Harpal S. Randeva |
Abstract |
Familial hypercholesterolemia (FH) is a common genetic cause of premature cardiovascular disease (CVD). The reported prevalence rates for both heterozygous FH (HeFH) and homozygous FH (HoFH) vary significantly, and this can be attributed, at least in part, to the variable diagnostic criteria used across different populations. Due to lack of consistent data, new global registries and unified guidelines are being formed, which are expected to advance current knowledge and improve the care of FH patients. This review presents a comprehensive overview of the pathophysiology, epidemiology, manifestations, and pharmacological treatment of FH, whilst summarizing the up-to-date relevant recommendations and guidelines. Ongoing research in FH seems promising and novel therapies are expected to be introduced in clinical practice in order to compliment or even substitute current treatment options, aiming for better lipid-lowering effects, fewer side effects, and improved clinical outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 208 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 35 | 17% |
Researcher | 18 | 9% |
Student > Master | 18 | 9% |
Student > Ph. D. Student | 16 | 8% |
Student > Doctoral Student | 14 | 7% |
Other | 37 | 18% |
Unknown | 70 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 46 | 22% |
Biochemistry, Genetics and Molecular Biology | 29 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
Nursing and Health Professions | 11 | 5% |
Agricultural and Biological Sciences | 10 | 5% |
Other | 16 | 8% |
Unknown | 83 | 40% |