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Mendeley readers
Attention Score in Context
| Title |
Similar Structures but Different Roles – An Updated Perspective on TLR Structures
|
|---|---|
| Published in |
Frontiers in Physiology, January 2011
|
| DOI | 10.3389/fphys.2011.00041 |
| Pubmed ID | |
| Authors |
Balachandran Manavalan, Shaherin Basith, Sangdun Choi |
| Abstract |
Toll-like receptors (TLRs) are pattern recognition receptors that recognize conserved structures in pathogens, trigger innate immune responses, and prime antigen-specific adaptive immunity. Elucidation of crystal structures of TLRs interacting with their ligands such as TLR1-2 with triacylated lipopeptide, TLR2-6 with diacylated lipopeptide, TLR4-MD-2 with LPS, and TLR3 with double-stranded RNA (dsRNA) have enabled an understanding of the initiation of TLR signaling. Agonistic ligands such as LPS, dsRNA, and lipopeptides induce "m" shaped TLR dimers in which C-termini converge at the center. Such central convergence is necessary to bring the two intracellular receptor TIR domains closer together and promote their dimerization, which serves as an essential step in downstream signaling. In this review, we summarize TLR ECD structures that have been reported to date with special emphasis on ligand recognition and activation mechanism. |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| India | 2 | 1% |
| France | 2 | 1% |
| United States | 2 | 1% |
| Canada | 2 | 1% |
| Turkey | 1 | <1% |
| United Kingdom | 1 | <1% |
| Estonia | 1 | <1% |
| Egypt | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 145 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 25% |
| Student > Master | 31 | 19% |
| Researcher | 25 | 16% |
| Student > Bachelor | 17 | 11% |
| Professor > Associate Professor | 8 | 5% |
| Other | 21 | 13% |
| Unknown | 17 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 35% |
| Biochemistry, Genetics and Molecular Biology | 25 | 16% |
| Chemistry | 15 | 9% |
| Medicine and Dentistry | 13 | 8% |
| Immunology and Microbiology | 12 | 8% |
| Other | 17 | 11% |
| Unknown | 21 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#20,167,959
of 22,679,690 outputs
Outputs from Frontiers in Physiology
#9,273
of 13,472 outputs
Outputs of similar age
#169,861
of 180,339 outputs
Outputs of similar age from Frontiers in Physiology
#34
of 47 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,472 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,339 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.