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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Splicing Factor SRSF1 as a Marker for Endothelial Senescence
|
|---|---|
| Published in |
Frontiers in Physiology, January 2012
|
| DOI | 10.3389/fphys.2012.00054 |
| Pubmed ID | |
| Authors |
Francisco Javier Blanco, Carmelo Bernabéu |
| Abstract |
Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of the endothelial cells (ECs) that line the lumen of blood vessels is the cellular basis for these age-dependent vascular pathologies, including atherosclerosis and hypertension. During their lifespan, ECs may reach a stage of senescence by two different pathways; a replicative one derived from their preprogrammed finite number of cell divisions; and one induced by stress stimuli. Also, certain physiological stimuli, such as transforming growth factor-β, are able to modulate cellular senescence. Currently, the cellular aging process is being widely studied to identify novel molecular markers whose changes correlate with senescence. This review focuses on the regulation of alternative splicing mediated by the serine-arginine splicing factor 1 (SRSF1, or ASF/SF2) during endothelial senescence, a process that is associated with a differential subcellular localization of SRSF1, which typically exhibits a scattered distribution throughout the cytoplasm. Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 82 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 31% |
| Researcher | 17 | 20% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 7 | 8% |
| Professor | 5 | 6% |
| Other | 10 | 11% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 33% |
| Agricultural and Biological Sciences | 27 | 31% |
| Medicine and Dentistry | 7 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Chemistry | 3 | 3% |
| Other | 7 | 8% |
| Unknown | 11 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#6,924,994
of 25,223,158 outputs
Outputs from Frontiers in Physiology
#3,200
of 15,509 outputs
Outputs of similar age
#58,771
of 255,495 outputs
Outputs of similar age from Frontiers in Physiology
#63
of 310 outputs
Altmetric has tracked 25,223,158 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 15,509 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,495 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 310 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.