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Nerve-Cancer Interactions in the Stromal Biology of Pancreatic Cancer

Overview of attention for article published in Frontiers in Physiology, January 2012
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Title
Nerve-Cancer Interactions in the Stromal Biology of Pancreatic Cancer
Published in
Frontiers in Physiology, January 2012
DOI 10.3389/fphys.2012.00097
Pubmed ID
Authors

Ihsan Ekin Demir, Helmut Friess, Güralp O. Ceyhan

Abstract

Interaction of cancer cells with diverse cell types in the tumor stroma is today recognized to have a fate-determining role for the progression and outcome of human cancers. Despite the well-described interactions of cancer cells with several stromal components, i.e., inflammatory cells, cancer-associated fibroblasts, endothelial cells, and pericytes, the investigation of their peculiar relationship with neural cells is still at its first footsteps. Pancreatic cancer (PCa) with its abundant stroma represents one of the best-studied examples of a malignant tumor with a mutually trophic interaction between cancer cells and the intratumoral nerves embedded in the desmoplastic stroma. Nerves in PCa are a rich source of neurotrophic factors like nerve growth factor (NGF), glial-cell-derived neurotrophic factor (GDNF), artemin; of neuronal chemokines like fractalkine; and of autonomic neurotransmitters like norepinephrine which can all enhance the invasiveness of PCa cells via matrix-metalloproteinase (MMP) upregulation, trigger neural invasion (NI), and activate pro-survival signaling pathways. Similarly, PCa cells themselves provide intrapancreatic nerves with abundant trophic agents which entail a remarkable neuroplasticity, leading to emergence of more routes for NI and cancer spread, to augmented local neuro-surveillance, neural sensitization, and neuropathic pain. The strong correlation of NI with PCa-associated desmoplasia suggests the potential presence of a triangular relationship between nerves, PCa cells, and other stromal partners like myofibroblasts and pancreatic stellate cells which generate tumor desmoplasia. Hence, although not a classical hallmark of human cancers, nerve-cancer interactions can be considered as an indispensable sub-class of cancer-stroma interactions in PCa. The present article provides an overview of the so far known nerve-cancer interactions in PCa and illustrates their ominous role in the stromal biology of human PCa.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 3 3%
United States 2 2%
Ukraine 1 1%
Unknown 89 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 26%
Researcher 18 19%
Student > Doctoral Student 6 6%
Student > Bachelor 6 6%
Professor 5 5%
Other 17 18%
Unknown 18 19%
Readers by discipline Count As %
Medicine and Dentistry 22 23%
Biochemistry, Genetics and Molecular Biology 17 18%
Agricultural and Biological Sciences 14 15%
Neuroscience 6 6%
Immunology and Microbiology 3 3%
Other 11 12%
Unknown 22 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2012.
All research outputs
#15,249,959
of 22,675,759 outputs
Outputs from Frontiers in Physiology
#6,588
of 13,467 outputs
Outputs of similar age
#163,175
of 244,088 outputs
Outputs of similar age from Frontiers in Physiology
#154
of 309 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,467 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,088 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 309 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.