Title |
Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population
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Published in |
Frontiers in Physiology, January 2013
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DOI | 10.3389/fphys.2012.00496 |
Pubmed ID | |
Authors |
Kim-Anne Lê, Yan Li, Xiaojing Xu, Wanting Yang, Tingting Liu, Xiaoning Zhao, Yongming Gorge Tang, Dehong Cai, Vay Liang W. Go, Stephen Pandol, Hongxiang Hui |
Abstract |
Background: The connection between gut microbiota and metabolism and its role in the pathogenesis of diabetes are increasingly recognized. The objective of this study was to quantitatively measure Bifidobacterium and Lactobacillus species, members of commensal bacteria found in human gut, in type 2 diabetic patients (T2D) patients from Southern China.Methods: Fifty patients with T2D and thirty control individuals of similar body mass index (BMI) were recruited from Southern China. T2D and control subjects were confirmed with both oral glucose tolerance test (OGTT) and HbA(1c) measurements. Bifidobacterium and Lactobacillus species in feces were measured by real-time quantitative PCR. Data were analyzed with STATA 11.0 statistical software.Results: In comparison to control subjects T2D patients had significantly more total Lactobacillus (+18%), L. bugaricus (+13%), L. rhamnosum (+37%) and L. acidophilus (+48%) (P < 0.05). In contrast, T2D patients had less amounts of total Bifidobacteria (-7%) and B. adolescentis (-12%) (P < 0.05). Cluster analysis showed that gut microbiota pattern of T2D patients is characterized by greater numbers of L. rhamnosus and L. acidophillus, together with lesser numbers of B. adolescentis (P < 0.05).Conclusion: The gut microflora in T2D patients is characterized by greater numbers of Lactobacillus and lesser numbers of Bifidobacterium species. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Brazil | 1 | <1% |
Malaysia | 1 | <1% |
India | 1 | <1% |
United States | 1 | <1% |
Unknown | 112 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 19% |
Researcher | 15 | 13% |
Student > Bachelor | 15 | 13% |
Student > Ph. D. Student | 14 | 12% |
Other | 7 | 6% |
Other | 14 | 12% |
Unknown | 31 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 18% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Medicine and Dentistry | 16 | 14% |
Immunology and Microbiology | 8 | 7% |
Nursing and Health Professions | 7 | 6% |
Other | 14 | 12% |
Unknown | 36 | 31% |