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Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00055
Pubmed ID
Authors

Di Wu, Alexander K. Murashov

Abstract

MicroRNAs are small non-coding RNAs that suppress gene expression through target mRNA degradation or translation repression. Recent studies suggest that miRNA plays an important role in multiple physiological and pathological processes in the nervous system. In this review article, we described what is currently known about the mechanisms in peripheral nerve regeneration on cellular and molecular levels. Recently, changes in microRNA expression profiles have been detected in different injury models, and emerging evidence strongly indicates that these changes promote neurons to survive by shifting their physiology from maintaining structure and supporting synaptic transmission towards a regenerative phenotype. We reviewed the putative mechanisms involved in miRNA mediated post-transcriptional regulation and pointed out several areas where future research is necessary to advance our understanding of how targeting miRNA machinery can be used as a therapeutic approach for treating nerve injuries.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Israel 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 122 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 17%
Researcher 21 17%
Student > Bachelor 16 13%
Student > Postgraduate 12 10%
Student > Master 11 9%
Other 22 17%
Unknown 22 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 22%
Medicine and Dentistry 24 19%
Neuroscience 18 14%
Biochemistry, Genetics and Molecular Biology 14 11%
Engineering 4 3%
Other 11 9%
Unknown 27 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2018.
All research outputs
#19,842,681
of 25,257,066 outputs
Outputs from Frontiers in Physiology
#8,043
of 15,523 outputs
Outputs of similar age
#223,588
of 293,286 outputs
Outputs of similar age from Frontiers in Physiology
#197
of 399 outputs
Altmetric has tracked 25,257,066 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,523 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,286 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.