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Leptin expression affects metabolic rate in zebrafish embryos (D. rerio)

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
Leptin expression affects metabolic rate in zebrafish embryos (D. rerio)
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00160
Pubmed ID
Authors

Mark R. Dalman, Qin Liu, Mason D. King, Brian Bagatto, Richard L. Londraville

Abstract

We used antisense morpholino oligonucleotide technology to knockdown leptin-(A) gene expression in developing zebrafish embryos and measured its effects on metabolic rate and cardiovascular function. Using two indicators of metabolic rate, oxygen consumption was significantly lower in leptin morphants early in development [<48 hours post-fertilization (hpf)], while acid production was significantly lower in morphants later in development (>48 hpf). Oxygen utilization rates in <48 hpf embryos and acid production in 72 hpf embryos could be rescued to that of wildtype embryos by recombinant leptin coinjected with antisense morpholino. Leptin is established to influence metabolic rate in mammals, and these data suggest leptin signaling also influences metabolic rate in fishes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 30%
Student > Master 8 17%
Student > Bachelor 7 15%
Researcher 4 9%
Student > Postgraduate 2 4%
Other 5 11%
Unknown 7 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 38%
Biochemistry, Genetics and Molecular Biology 10 21%
Environmental Science 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Veterinary Science and Veterinary Medicine 2 4%
Other 5 11%
Unknown 8 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2013.
All research outputs
#15,274,055
of 22,713,403 outputs
Outputs from Frontiers in Physiology
#6,610
of 13,524 outputs
Outputs of similar age
#181,521
of 280,747 outputs
Outputs of similar age from Frontiers in Physiology
#188
of 398 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,524 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,747 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.