You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The sigma-1 receptor: a regulator of cancer cell electrical plasticity?
|
|---|---|
| Published in |
Frontiers in Physiology, January 2013
|
| DOI | 10.3389/fphys.2013.00175 |
| Pubmed ID | |
| Authors |
David Crottès, Hélène Guizouarn, Patrick Martin, Franck Borgese, Olivier Soriani |
| Abstract |
Originally mistaken as an opioid receptor, the sigma-1 receptor (Sig1R) is a ubiquitous membrane protein that has been involved in many cellular processes. While the precise function of Sig1R has long remained mysterious, recent studies have shed light on its role and the molecular mechanisms triggered. Sig1R is in fact a stress-activated chaperone mainly associated with the ER-mitochondria interface that can regulate cell survival through the control of calcium homeostasis. Sig1R functionally regulates ion channels belonging to various molecular families and it has thus been involved in neuronal plasticity and central nervous system diseases. Interestingly, Sig1R is frequently expressed in tumors but its function in cancer has not been yet clarified. In this review, we discuss the current understanding of Sig1R. We suggest herein that Sig1R shapes cancer cell electrical signature upon environmental conditions. Thus, Sig1R may be used as a novel therapeutic target to specifically abrogate pro-invasive functions of ion channels in cancer tissue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Canada | 2 | 3% |
| Unknown | 67 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 27% |
| Researcher | 10 | 14% |
| Professor > Associate Professor | 7 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 25% |
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Medicine and Dentistry | 5 | 7% |
| Chemistry | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 14 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2023.
All research outputs
#3,288,817
of 23,318,744 outputs
Outputs from Frontiers in Physiology
#1,757
of 14,050 outputs
Outputs of similar age
#34,833
of 283,761 outputs
Outputs of similar age from Frontiers in Physiology
#57
of 398 outputs
Altmetric has tracked 23,318,744 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,050 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,761 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.