Title |
Emerging key roles for P2X receptors in the kidney
|
---|---|
Published in |
Frontiers in Physiology, January 2013
|
DOI | 10.3389/fphys.2013.00262 |
Pubmed ID | |
Authors |
R. E. Birch, E. M. Schwiebert, C. M. Peppiatt-Wildman, S. S. Wildman |
Abstract |
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature describing a regulatory role of P2 receptors (P2R) in the kidney, there are significantly less data on the regulatory role of P2X receptors (P2XR) compared with that described for metabotropic P2Y. Much of the historical literature describing a role for P2XR in the kidney has focused heavily on the role of P2X1R in the autoregulation of renal blood flow. More recently, however, there has been a plethora of manuscripts providing compelling evidence for additional roles for P2XR in both kidney health and disease. This review summarizes the current evidence for the involvement of P2XR in the regulation of renal tubular and vascular function, and highlights the novel data describing their putative roles in regulating physiological and pathophysiological processes in the kidney. |
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Switzerland | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Spain | 1 | 3% |
China | 1 | 3% |
Unknown | 26 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 24% |
Researcher | 4 | 14% |
Student > Bachelor | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 5 | 17% |
Unknown | 6 | 21% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Neuroscience | 2 | 7% |
Other | 1 | 3% |
Unknown | 6 | 21% |