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Emerging key roles for P2X receptors in the kidney

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
Emerging key roles for P2X receptors in the kidney
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00262
Pubmed ID
Authors

R. E. Birch, E. M. Schwiebert, C. M. Peppiatt-Wildman, S. S. Wildman

Abstract

P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature describing a regulatory role of P2 receptors (P2R) in the kidney, there are significantly less data on the regulatory role of P2X receptors (P2XR) compared with that described for metabotropic P2Y. Much of the historical literature describing a role for P2XR in the kidney has focused heavily on the role of P2X1R in the autoregulation of renal blood flow. More recently, however, there has been a plethora of manuscripts providing compelling evidence for additional roles for P2XR in both kidney health and disease. This review summarizes the current evidence for the involvement of P2XR in the regulation of renal tubular and vascular function, and highlights the novel data describing their putative roles in regulating physiological and pathophysiological processes in the kidney.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Spain 1 3%
China 1 3%
Unknown 26 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 24%
Researcher 4 14%
Student > Bachelor 3 10%
Professor > Associate Professor 2 7%
Student > Master 2 7%
Other 5 17%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 9 31%
Agricultural and Biological Sciences 5 17%
Biochemistry, Genetics and Molecular Biology 4 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Neuroscience 2 7%
Other 1 3%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2013.
All research outputs
#20,203,867
of 22,723,682 outputs
Outputs from Frontiers in Physiology
#9,312
of 13,531 outputs
Outputs of similar age
#248,790
of 280,763 outputs
Outputs of similar age from Frontiers in Physiology
#243
of 398 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.