Title |
Defining a role for non-satellite stem cells in the regulation of muscle repair following exercise
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Published in |
Frontiers in Physiology, January 2013
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DOI | 10.3389/fphys.2013.00310 |
Pubmed ID | |
Authors |
Marni D. Boppart, Michael De Lisio, Kai Zou, Heather D. Huntsman |
Abstract |
Skeletal muscle repair is essential for effective remodeling, tissue maintenance, and initiation of beneficial adaptations post-eccentric exercise. A series of well characterized events, such as recruitment of immune cells and activation of satellite cells, constitute the basis for muscle regeneration. However, details regarding the fine-tuned regulation of this process in response to different types of injury are open for investigation. Muscle-resident non-myogenic, non-satellite stem cells expressing conventional mesenchymal stem cell (MSC) markers, have the potential to significantly contribute to regeneration given the role for bone marrow-derived MSCs in whole body tissue repair in response to injury and disease. The purpose of this mini-review is to highlight a regulatory role for Pnon-satellite stem cells in the process of skeletal muscle healing post-eccentric exercise. The non-myogenic, non-satellite stem cell fraction will be defined, its role in tissue repair will be briefly reviewed, and recent studies demonstrating a contribution to eccentric exercise-induced regeneration will be presented. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 18% |
United Kingdom | 2 | 18% |
Chile | 1 | 9% |
Norway | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 55% |
Scientists | 4 | 36% |
Unknown | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Italy | 1 | <1% |
Russia | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 117 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 18% |
Researcher | 17 | 14% |
Student > Bachelor | 16 | 13% |
Student > Master | 16 | 13% |
Student > Postgraduate | 10 | 8% |
Other | 28 | 23% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 20% |
Medicine and Dentistry | 22 | 18% |
Sports and Recreations | 19 | 15% |
Biochemistry, Genetics and Molecular Biology | 18 | 15% |
Veterinary Science and Veterinary Medicine | 2 | 2% |
Other | 13 | 11% |
Unknown | 24 | 20% |