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The possible impact of persistent virus infection on the function of the RNAi machinery in insects: a hypothesis

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
The possible impact of persistent virus infection on the function of the RNAi machinery in insects: a hypothesis
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00319
Pubmed ID
Authors

Luc Swevers, Jozef Vanden Broeck, Guy Smagghe

Abstract

RNAi experiments in insects are characterized by great variability in efficiency; for instance beetles and locusts are very amenable to dsRNA-mediated gene silencing, while other insect groups, most notably lepidopterans, are more refractory to RNAi. Several factors can be forwarded that could affect the efficiency of RNAi, such as the composition and function of the intracellular RNAi machinery, the mechanism of dsRNA uptake, the presence of dsRNA- and siRNA-degrading enzymes and non-specific activation of the innate immune response. In this essay, we investigate the evidence whether persistent infection with RNA viruses could be a major factor that affects the response to exogenous dsRNA in insects. The occurrence of RNA viruses in different insect groups will be discussed, as well as several mechanisms by which viruses could interfere with the process of RNAi. Finally, the impact of RNA virus infection on the design of dsRNA-based insect control strategies will be considered.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Slovenia 1 1%
Unknown 99 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 23%
Researcher 21 21%
Student > Master 17 17%
Student > Bachelor 13 13%
Professor 7 7%
Other 8 8%
Unknown 11 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 56%
Biochemistry, Genetics and Molecular Biology 19 19%
Engineering 3 3%
Nursing and Health Professions 1 1%
Veterinary Science and Veterinary Medicine 1 1%
Other 8 8%
Unknown 12 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2013.
All research outputs
#20,209,145
of 22,729,647 outputs
Outputs from Frontiers in Physiology
#9,312
of 13,537 outputs
Outputs of similar age
#248,798
of 280,769 outputs
Outputs of similar age from Frontiers in Physiology
#243
of 398 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.