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Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00340
Pubmed ID
Authors

Elena Panayiotou, Stavros Malas

Abstract

Spinal cord injury (SCI) is a major health burden and currently there is no effective medical intervention. Research performed over the last decade revealed that cells surrounding the central canal of the adult spinal cord and forming the ependymal layer acquire stem cell properties either in vitro or in response to injury. Following SCI activated ependymal cells generate progeny cells which migrate to the injury site but fail to produce the appropriate type of cells in sufficient number to limit the damage, rendering this physiological response mainly ineffective. Research is now focusing on the manipulation of ependymal cells to produce cells of the oligodendrocyte lineage which are primarily lost in such a situation leading to secondary neuronal degeneration. Thus, there is a need for a more focused approach to understand the molecular properties of adult ependymal cells in greater detail and develop effective strategies for guiding their response during SCI.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Student > Bachelor 13 18%
Researcher 11 15%
Student > Master 9 12%
Student > Postgraduate 3 4%
Other 8 11%
Unknown 14 19%
Readers by discipline Count As %
Neuroscience 18 25%
Agricultural and Biological Sciences 16 22%
Medicine and Dentistry 11 15%
Biochemistry, Genetics and Molecular Biology 5 7%
Engineering 4 5%
Other 3 4%
Unknown 16 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2013.
All research outputs
#20,211,690
of 22,733,113 outputs
Outputs from Frontiers in Physiology
#9,311
of 13,539 outputs
Outputs of similar age
#248,813
of 280,780 outputs
Outputs of similar age from Frontiers in Physiology
#243
of 398 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,539 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,780 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.