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Acid-base transport in pancreas—new challenges

Overview of attention for article published in Frontiers in Physiology, January 2013
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Title
Acid-base transport in pancreas—new challenges
Published in
Frontiers in Physiology, January 2013
DOI 10.3389/fphys.2013.00380
Pubmed ID
Authors

Ivana Novak, Kristian A. Haanes, Jing Wang

Abstract

Along the gastrointestinal tract a number of epithelia contribute with acid or basic secretions in order to aid digestive processes. The stomach and pancreas are the most extreme examples of acid (H(+)) and base (HCO(-)3) transporters, respectively. Nevertheless, they share the same challenges of transporting acid and bases across epithelia and effectively regulating their intracellular pH. In this review, we will make use of comparative physiology to enlighten the cellular mechanisms of pancreatic HCO(-)3 and fluid secretion, which is still challenging physiologists. Some of the novel transporters to consider in pancreas are the proton pumps (H(+)-K(+)-ATPases), as well as the calcium-activated K(+) and Cl(-) channels, such as KCa3.1 and TMEM16A/ANO1. Local regulators, such as purinergic signaling, fine-tune, and coordinate pancreatic secretion. Lastly, we speculate whether dys-regulation of acid-base transport contributes to pancreatic diseases including cystic fibrosis, pancreatitis, and cancer.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Denmark 1 3%
Unknown 35 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Student > Master 5 14%
Researcher 5 14%
Student > Bachelor 4 11%
Other 2 5%
Other 3 8%
Unknown 11 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Biochemistry, Genetics and Molecular Biology 8 22%
Medicine and Dentistry 4 11%
Chemistry 2 5%
Sports and Recreations 1 3%
Other 3 8%
Unknown 10 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2017.
All research outputs
#15,288,160
of 22,736,112 outputs
Outputs from Frontiers in Physiology
#6,621
of 13,539 outputs
Outputs of similar age
#181,584
of 280,808 outputs
Outputs of similar age from Frontiers in Physiology
#188
of 398 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,539 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,808 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 398 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.