Title |
Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy
|
---|---|
Published in |
Frontiers in Physiology, January 2013
|
DOI | 10.3389/fphys.2013.00384 |
Pubmed ID | |
Authors |
Angara Sureshbabu, Vineet Bhandari |
Abstract |
During mild stressful conditions, cells activate a multitude of mechanisms in an attempt to repair or re-establish homeostasis. One such mechanism is autophagic degradation of mitochondria or mitophagy to dispose damaged mitochondria. However, if stress persists beyond recovery then dysfunctional mitochondria can ignite cell death. This review article summarizes recent studies highlighting the molecular pathways that facilitate mitochondria to alter its morphological dynamics, coordinate stress responses, initiate mitophagy and activate cell death in relevance to pulmonary pathologies. Thorough understanding of how these signaling mechanisms get disrupted may aid in designing new mitochondria-based therapies to combat lung diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 30% |
Researcher | 10 | 14% |
Student > Master | 4 | 6% |
Student > Doctoral Student | 4 | 6% |
Student > Bachelor | 3 | 4% |
Other | 12 | 17% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 22% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Agricultural and Biological Sciences | 11 | 16% |
Immunology and Microbiology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 6 | 9% |
Unknown | 18 | 26% |