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Mendeley readers
Attention Score in Context
| Title |
Intracellular pH regulation by acid-base transporters in mammalian neurons
|
|---|---|
| Published in |
Frontiers in Physiology, January 2014
|
| DOI | 10.3389/fphys.2014.00043 |
| Pubmed ID | |
| Authors |
Vernon A. Ruffin, Ahlam I. Salameh, Walter F. Boron, Mark D. Parker |
| Abstract |
Intracellular pH (pHi) regulation in the brain is important in both physiological and physiopathological conditions because changes in pHi generally result in altered neuronal excitability. In this review, we will cover 4 major areas: (1) The effect of pHi on cellular processes in the brain, including channel activity and neuronal excitability. (2) pHi homeostasis and how it is determined by the balance between rates of acid loading (J L) and extrusion (J E). The balance between J E and J L determine steady-state pHi, as well as the ability of the cell to defend pHi in the face of extracellular acid-base disturbances (e.g., metabolic acidosis). (3) The properties and importance of members of the SLC4 and SLC9 families of acid-base transporters expressed in the brain that contribute to J L (namely the Cl-HCO3 exchanger AE3) and J E (the Na-H exchangers NHE1, NHE3, and NHE5 as well as the Na(+)- coupled HCO3 (-) transporters NBCe1, NBCn1, NDCBE, and NBCn2). (4) The effect of acid-base disturbances on neuronal function and the roles of acid-base transporters in defending neuronal pHi under physiopathologic conditions. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 226 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 22% |
| Researcher | 32 | 14% |
| Student > Bachelor | 31 | 13% |
| Student > Master | 14 | 6% |
| Student > Postgraduate | 13 | 6% |
| Other | 36 | 16% |
| Unknown | 55 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 20% |
| Neuroscience | 36 | 16% |
| Biochemistry, Genetics and Molecular Biology | 32 | 14% |
| Medicine and Dentistry | 22 | 9% |
| Chemistry | 13 | 6% |
| Other | 24 | 10% |
| Unknown | 58 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2020.
All research outputs
#13,328,150
of 22,743,667 outputs
Outputs from Frontiers in Physiology
#4,519
of 13,552 outputs
Outputs of similar age
#162,369
of 305,223 outputs
Outputs of similar age from Frontiers in Physiology
#50
of 106 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,552 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,223 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.