Title |
Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways
|
---|---|
Published in |
Frontiers in Physiology, March 2014
|
DOI | 10.3389/fphys.2014.00103 |
Pubmed ID | |
Authors |
Immo A. Hansen, Geoffrey M. Attardo, Stacy D. Rodriguez, Lisa L. Drake |
Abstract |
Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related signals activate it and expression levels rise rapidly. The best understood example of yolk protein precursor gene regulation is the vitellogenin-A gene (vg) of the yellow fever mosquito Aedes aegypti. Vg-A is regulated by (1) juvenile hormone signaling, (2) the ecdysone-signaling cascade, (3) the nutrient sensitive target-of-rapamycin signaling pathway, and (4) the insulin-like peptide (ILP) signaling pathway. A plethora of new studies have refined our understanding of the regulation of yolk protein precursor genes since the last review on this topic in 2005 (Attardo et al., 2005). This review summarizes the role of these four signaling pathways in the regulation of vg-A and focuses upon new findings regarding the interplay between them on an organismal level. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Spain | 2 | 1% |
Portugal | 1 | <1% |
United Kingdom | 1 | <1% |
France | 1 | <1% |
Brazil | 1 | <1% |
China | 1 | <1% |
Unknown | 175 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 43 | 23% |
Researcher | 27 | 15% |
Student > Master | 26 | 14% |
Student > Doctoral Student | 15 | 8% |
Student > Bachelor | 14 | 8% |
Other | 27 | 15% |
Unknown | 34 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 71 | 38% |
Biochemistry, Genetics and Molecular Biology | 50 | 27% |
Medicine and Dentistry | 6 | 3% |
Immunology and Microbiology | 6 | 3% |
Chemistry | 5 | 3% |
Other | 10 | 5% |
Unknown | 38 | 20% |