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Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

Overview of attention for article published in Frontiers in Physiology, April 2014
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Title
Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
Published in
Frontiers in Physiology, April 2014
DOI 10.3389/fphys.2014.00141
Pubmed ID
Authors

Joshua A. McCarroll, Stephanie Naim, George Sharbeen, Nelson Russia, Julia Lee, Maria Kavallaris, David Goldstein, Phoebe A. Phillips

Abstract

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 135 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 25%
Student > Master 21 15%
Student > Bachelor 15 11%
Researcher 14 10%
Student > Doctoral Student 8 6%
Other 20 15%
Unknown 24 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 46 34%
Medicine and Dentistry 26 19%
Agricultural and Biological Sciences 16 12%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Engineering 5 4%
Other 10 7%
Unknown 28 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2014.
All research outputs
#18,370,767
of 22,753,345 outputs
Outputs from Frontiers in Physiology
#8,089
of 13,559 outputs
Outputs of similar age
#165,370
of 228,038 outputs
Outputs of similar age from Frontiers in Physiology
#66
of 97 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,559 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.