Title |
Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
|
---|---|
Published in |
Frontiers in Physiology, April 2014
|
DOI | 10.3389/fphys.2014.00141 |
Pubmed ID | |
Authors |
Joshua A. McCarroll, Stephanie Naim, George Sharbeen, Nelson Russia, Julia Lee, Maria Kavallaris, David Goldstein, Phoebe A. Phillips |
Abstract |
Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Unknown | 135 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 25% |
Student > Master | 21 | 15% |
Student > Bachelor | 15 | 11% |
Researcher | 14 | 10% |
Student > Doctoral Student | 8 | 6% |
Other | 20 | 15% |
Unknown | 24 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 46 | 34% |
Medicine and Dentistry | 26 | 19% |
Agricultural and Biological Sciences | 16 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Engineering | 5 | 4% |
Other | 10 | 7% |
Unknown | 28 | 21% |