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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
|
|---|---|
| Published in |
Frontiers in Physiology, June 2014
|
| DOI | 10.3389/fphys.2014.00212 |
| Pubmed ID | |
| Authors |
Yvonne Döring, Lukas Pawig, Christian Weber, Heidi Noels |
| Abstract |
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) as an important second ligand for CXCR4, and of CXCR7 as an alternative receptor for CXCL12, has undermined this interpretation and has considerably complicated the understanding of CXCL12/CXCR4 signaling and associated biological functions. This review aims to provide insight into the current concept of the CXCL12/CXCR4 axis in myocardial infarction (MI) and its underlying pathologies such as atherosclerosis and injury-induced vascular restenosis. It will discuss main findings from in vitro studies, animal experiments and large-scale genome-wide association studies. The importance of the CXCL12/CXCR4 axis in progenitor cell homing and mobilization will be addressed, as will be the function of CXCR4 in different cell types involved in atherosclerosis. Finally, a potential translation of current knowledge on CXCR4 into future therapeutical application will be discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 304 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | <1% |
| United States | 3 | <1% |
| Sweden | 1 | <1% |
| Japan | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 295 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 26% |
| Researcher | 45 | 15% |
| Student > Master | 34 | 11% |
| Student > Bachelor | 27 | 9% |
| Student > Doctoral Student | 25 | 8% |
| Other | 29 | 10% |
| Unknown | 66 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 64 | 21% |
| Biochemistry, Genetics and Molecular Biology | 60 | 20% |
| Agricultural and Biological Sciences | 42 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 5% |
| Chemistry | 12 | 4% |
| Other | 36 | 12% |
| Unknown | 75 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from Frontiers in Physiology
#9,328
of 13,560 outputs
Outputs of similar age
#193,279
of 228,651 outputs
Outputs of similar age from Frontiers in Physiology
#68
of 102 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,560 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,651 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.