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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vitamin D and adipose tissue—more than storage
|
|---|---|
| Published in |
Frontiers in Physiology, June 2014
|
| DOI | 10.3389/fphys.2014.00228 |
| Pubmed ID | |
| Authors |
Shivaprakash J. Mutt, Elina Hyppönen, Juha Saarnio, Marjo-Riitta Järvelin, Karl-Heinz Herzig |
| Abstract |
The pandemic increase in obesity is inversely associated with vitamin D levels. While a higher BMI was causally related to lower 25-hydroxyvitamin D (25(OH)D), no evidence was obtained for a BMI lowering effect by higher 25(OH)D. Some of the physiological functions of 1,25(OH)2D3 (1,25-dihydroxycholecalciferol or calcitriol) via its receptor within the adipose tissue have been investigated such as its effect on energy balance, adipogenesis, adipokine, and cytokine secretion. Adipose tissue inflammation has been recognized as the key component of metabolic disorders, e.g., in the metabolic syndrome. The adipose organ secretes more than 260 different proteins/peptides. However, the molecular basis of the interactions of 1,25(OH)2D3, vitamin D binding proteins (VDBPs) and nuclear vitamin D receptor (VDR) after sequestration in adipose tissue and their regulations are still unclear. 1,25(OH)2D3 and its inactive metabolites are known to inhibit the formation of adipocytes in mouse 3T3-L1 cell line. In humans, 1,25(OH)2D3 promotes preadipocyte differentiation under cell culture conditions. Further evidence of its important functions is given by VDR knock out (VDR(-/-)) and CYP27B1 knock out (CYP27B1 (-/-)) mouse models: Both VDR(-/-) and CYP27B1(-/-) models are highly resistant to the diet induced weight gain, while the specific overexpression of human VDR in adipose tissue leads to increased adipose tissue mass. The analysis of microarray datasets from human adipocytes treated with macrophage-secreted products up-regulated VDR and CYP27B1 genes indicating the capacity of adipocytes to even produce active 1,25(OH)2D3. Experimental studies demonstrate that 1,25(OH)2D3 has an active role in adipose tissue by modulating inflammation, adipogenesis and adipocyte secretion. Yet, further in vivo studies are needed to address the effects and the effective dosages of vitamin D in human adipose tissue and its relevance in the associated diseases. |
X Demographics
The data shown below were collected from the profiles of 70 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 19 | 27% |
| Congo | 1 | 1% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Poland | 1 | 1% |
| India | 1 | 1% |
| Sweden | 1 | 1% |
| Unknown | 45 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 68 | 97% |
| Scientists | 1 | 1% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | <1% |
| South Africa | 1 | <1% |
| Finland | 1 | <1% |
| Mexico | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 209 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 14% |
| Student > Master | 30 | 14% |
| Student > Bachelor | 24 | 11% |
| Researcher | 21 | 10% |
| Other | 17 | 8% |
| Other | 51 | 24% |
| Unknown | 41 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 61 | 29% |
| Agricultural and Biological Sciences | 35 | 16% |
| Biochemistry, Genetics and Molecular Biology | 26 | 12% |
| Nursing and Health Professions | 16 | 7% |
| Chemistry | 4 | 2% |
| Other | 26 | 12% |
| Unknown | 46 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2022.
All research outputs
#1,064,267
of 25,732,188 outputs
Outputs from Frontiers in Physiology
#583
of 15,722 outputs
Outputs of similar age
#10,133
of 243,746 outputs
Outputs of similar age from Frontiers in Physiology
#5
of 99 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,722 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,746 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.