Title |
Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction
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Published in |
Frontiers in Physiology, July 2014
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DOI | 10.3389/fphys.2014.00259 |
Pubmed ID | |
Authors |
Istvan Czikora, Supriya Sridhar, Boris Gorshkov, Irina B. Alieva, Anita Kasa, Joyce Gonzales, Olena Potapenko, Nagavedi S. Umapathy, Helena Pillich, Ferenc G. Rick, Norman L. Block, Alexander D. Verin, Trinad Chakraborty, Michael A. Matthay, Andrew V. Schally, Rudolf Lucas |
Abstract |
Antibiotic treatment of patients infected with G(-) or G(+) bacteria promotes release of the toxins lipopolysaccharide (LPS) and pneumolysin (PLY) in their lungs. Growth Hormone-releasing Hormone (GHRH) agonist JI-34 protects human lung microvascular endothelial cells (HL-MVEC), expressing splice variant 1 (SV-1) of the receptor, from PLY-induced barrier dysfunction. We investigated whether JI-34 also blunts LPS-induced hyperpermeability. Since GHRH receptor (GHRH-R) signaling can potentially stimulate both cAMP-dependent barrier-protective pathways as well as barrier-disruptive protein kinase C pathways, we studied their interaction in GHRH agonist-treated HL-MVEC, in the presence of PLY, by means of siRNA-mediated protein kinase A (PKA) depletion. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 18% |
Student > Ph. D. Student | 4 | 18% |
Professor | 2 | 9% |
Other | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Other | 2 | 9% |
Unknown | 6 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 27% |
Agricultural and Biological Sciences | 2 | 9% |
Business, Management and Accounting | 1 | 5% |
Computer Science | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 3 | 14% |
Unknown | 8 | 36% |