Title |
Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation
|
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Published in |
Frontiers in Physiology, July 2014
|
DOI | 10.3389/fphys.2014.00279 |
Pubmed ID | |
Authors |
Dimitry A. Chistiakov, Alexander N. Orekhov, Igor A. Sobenin, Yuri V. Bobryshev |
Abstract |
Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady state and in pathology. In atherosclerosis, pDCs are involved in priming vascular inflammation and atherogenesis through production of IFN-I and chemokines that attract inflammatory cells to inflamed sites. pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 1% |
Japan | 1 | <1% |
Unknown | 159 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 19% |
Student > Bachelor | 31 | 19% |
Student > Master | 26 | 16% |
Researcher | 21 | 13% |
Other | 6 | 4% |
Other | 14 | 9% |
Unknown | 33 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 19% |
Biochemistry, Genetics and Molecular Biology | 30 | 19% |
Immunology and Microbiology | 25 | 15% |
Medicine and Dentistry | 23 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 13 | 8% |
Unknown | 36 | 22% |