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Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

Overview of attention for article published in Frontiers in Physiology, October 2014
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Title
Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications
Published in
Frontiers in Physiology, October 2014
DOI 10.3389/fphys.2014.00385
Pubmed ID
Authors

Felicitas S. Boretti, Jin Hyen Baek, Andre F. Palmer, Dominik J. Schaer, Paul W. Buehler

Abstract

Haptoglobin (Hp) prevents hemoglobin (Hb) extravasation and attenuates Hb induced tissue oxidation and vasoconstriction. Small animal models such as mouse, rat and guinea pig appear to demonstrate proof-of-concept for Hb neutralization by Hp in diverse pre-clinical conditions. However, these species differ significantly from humans in the clearance of Hb:Hp and demonstrate long persistence of circulating Hb:Hp complexes.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Brazil 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Other 3 11%
Researcher 3 11%
Student > Postgraduate 2 7%
Student > Master 2 7%
Other 4 15%
Unknown 7 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 15%
Medicine and Dentistry 4 15%
Immunology and Microbiology 3 11%
Chemical Engineering 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 5 19%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2014.
All research outputs
#20,238,443
of 22,765,347 outputs
Outputs from Frontiers in Physiology
#9,333
of 13,560 outputs
Outputs of similar age
#213,164
of 255,208 outputs
Outputs of similar age from Frontiers in Physiology
#80
of 125 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,560 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,208 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.