Title |
BK channel activators and their therapeutic perspectives
|
---|---|
Published in |
Frontiers in Physiology, October 2014
|
DOI | 10.3389/fphys.2014.00389 |
Pubmed ID | |
Authors |
Bo H. Bentzen, Søren-Peter Olesen, Lars C. B. Rønn, Morten Grunnet |
Abstract |
The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 161 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 22% |
Researcher | 22 | 13% |
Student > Bachelor | 20 | 12% |
Student > Master | 20 | 12% |
Professor > Associate Professor | 8 | 5% |
Other | 24 | 14% |
Unknown | 36 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 20% |
Biochemistry, Genetics and Molecular Biology | 25 | 15% |
Neuroscience | 22 | 13% |
Medicine and Dentistry | 19 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 9% |
Other | 15 | 9% |
Unknown | 37 | 22% |