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Surveying the floodgates: estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae

Overview of attention for article published in Frontiers in Physiology, November 2014
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Surveying the floodgates: estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae
Published in
Frontiers in Physiology, November 2014
DOI 10.3389/fphys.2014.00444
Pubmed ID
Authors

Michael Vincent, Mark Whidden, Santiago Schnell

Abstract

Endoplasmic reticulum resident proteins, along with all proteins traveling through the secretory pathway must enter endoplasmic reticulum lumen through membrane-embedded translocons. In Saccharomyces cerevisiae the heterotrimeric endoplasmic reticulum translocon is composed of the Sec61p, Sss1p, and Sbh1p core subunits. While the involvement of various molecules associated with the Sec61 complex has been thoroughly characterized, little attention has been given to the overall flux through these channels. In this work we carried out a meta-analysis to estimate the average and absolute flux of proteins into the endoplasmic reticulum lumen. We estimate an average of 460 proteins enter the endoplasmic reticulum every second, with an absolute minimum and maximum flux of 78 and 3700 molecules per second, respectively. With current technologies limiting the ability to obtain accurate measurements of these events, our estimates shed light on the flow of protein entering the endoplasmic reticulum lumen.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 3%
United States 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Professor 5 16%
Student > Ph. D. Student 5 16%
Student > Doctoral Student 3 10%
Lecturer > Senior Lecturer 3 10%
Other 5 16%
Unknown 4 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 42%
Agricultural and Biological Sciences 9 29%
Physics and Astronomy 1 3%
Chemistry 1 3%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2014.
All research outputs
#15,148,446
of 23,299,593 outputs
Outputs from Frontiers in Physiology
#5,838
of 14,027 outputs
Outputs of similar age
#144,724
of 260,131 outputs
Outputs of similar age from Frontiers in Physiology
#35
of 114 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,027 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,131 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.