Title |
Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review
|
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Published in |
Frontiers in Physiology, March 2016
|
DOI | 10.3389/fphys.2016.00075 |
Pubmed ID | |
Authors |
Xue Zhang, Marcio Luis Acencio, Ney Lemke |
Abstract |
Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification of essential genes is very important not only for understanding the minimal requirements for survival of an organism, but also for finding human disease genes and new drug targets. Experimental methods for identifying essential genes are costly, time-consuming, and laborious. With the accumulation of sequenced genomes data and high-throughput experimental data, many computational methods for identifying essential proteins are proposed, which are useful complements to experimental methods. In this review, we show the state-of-the-art methods for identifying essential genes and proteins based on machine learning and network topological features, point out the progress and limitations of current methods, and discuss the challenges and directions for further research. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 141 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 21% |
Student > Bachelor | 23 | 16% |
Researcher | 22 | 15% |
Student > Master | 21 | 15% |
Student > Postgraduate | 10 | 7% |
Other | 12 | 8% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 20% |
Computer Science | 26 | 18% |
Biochemistry, Genetics and Molecular Biology | 25 | 17% |
Medicine and Dentistry | 9 | 6% |
Engineering | 7 | 5% |
Other | 18 | 13% |
Unknown | 29 | 20% |