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Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review

Overview of attention for article published in Frontiers in Physiology, March 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
4 X users
patent
1 patent

Citations

dimensions_citation
75 Dimensions

Readers on

mendeley
143 Mendeley
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1 CiteULike
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Title
Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review
Published in
Frontiers in Physiology, March 2016
DOI 10.3389/fphys.2016.00075
Pubmed ID
Authors

Xue Zhang, Marcio Luis Acencio, Ney Lemke

Abstract

Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification of essential genes is very important not only for understanding the minimal requirements for survival of an organism, but also for finding human disease genes and new drug targets. Experimental methods for identifying essential genes are costly, time-consuming, and laborious. With the accumulation of sequenced genomes data and high-throughput experimental data, many computational methods for identifying essential proteins are proposed, which are useful complements to experimental methods. In this review, we show the state-of-the-art methods for identifying essential genes and proteins based on machine learning and network topological features, point out the progress and limitations of current methods, and discuss the challenges and directions for further research.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Ireland 1 <1%
Unknown 141 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 21%
Student > Bachelor 23 16%
Researcher 22 15%
Student > Master 21 15%
Student > Postgraduate 10 7%
Other 12 8%
Unknown 25 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 20%
Computer Science 26 18%
Biochemistry, Genetics and Molecular Biology 25 17%
Medicine and Dentistry 9 6%
Engineering 7 5%
Other 18 13%
Unknown 29 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2021.
All research outputs
#6,160,805
of 22,854,458 outputs
Outputs from Frontiers in Physiology
#2,865
of 13,646 outputs
Outputs of similar age
#86,225
of 299,380 outputs
Outputs of similar age from Frontiers in Physiology
#36
of 140 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 13,646 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,380 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.