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The Roles of Acidosis in Osteoclast Biology

Overview of attention for article published in Frontiers in Physiology, June 2016
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Title
The Roles of Acidosis in Osteoclast Biology
Published in
Frontiers in Physiology, June 2016
DOI 10.3389/fphys.2016.00222
Pubmed ID
Authors

Feng-Lai Yuan, Ming-Hui Xu, Xia Li, He Xinlong, Wei Fang, Jian Dong

Abstract

The adverse effect of acidosis on the skeletal system has been recognized for almost a century. Although the underlying mechanism has not been fully elucidated, it appears that acidosis acts as a general stimulator of osteoclasts derived from bone marrow precursors cells and enhances osteoclastic resorption. Prior work suggests that acidosis plays a significant role in osteoclasts formation and activation via up-regulating various genes responsible for its adhesion, migration, survival and bone matrix degradation. Understanding the role of acidosis in osteoclast biology may lead to development of novel therapeutic approaches for the treatment of diseases related to low bone mass. In this review, we aim to discuss the recent investigations into the effects of acidosis in osteoclast biology and the acid-sensing molecular mechanism.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 21%
Student > Bachelor 8 12%
Student > Ph. D. Student 7 10%
Other 6 9%
Student > Master 5 7%
Other 7 10%
Unknown 20 30%
Readers by discipline Count As %
Medicine and Dentistry 10 15%
Biochemistry, Genetics and Molecular Biology 6 9%
Agricultural and Biological Sciences 5 7%
Engineering 5 7%
Materials Science 3 4%
Other 14 21%
Unknown 24 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2016.
All research outputs
#20,334,427
of 22,879,161 outputs
Outputs from Frontiers in Physiology
#9,417
of 13,671 outputs
Outputs of similar age
#305,328
of 352,727 outputs
Outputs of similar age from Frontiers in Physiology
#117
of 171 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,671 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,727 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.