Title |
“Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior
|
---|---|
Published in |
Frontiers in Physiology, July 2016
|
DOI | 10.3389/fphys.2016.00306 |
Pubmed ID | |
Authors |
Raj Sewduth, Massimo M. Santoro |
Abstract |
Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Here we highlight some recent argument on new players that are critical in endothelial cells, by summarizing novel discoveries that regulate notorious vascular pathways such as Vascular Endothelial Growth Factor (VEGF), Notch and Planar Cell Polarity (PCP), and by discussing more recent findings that put metabolism, redox signaling and hemodynamic forces as novel unforeseen facets in angiogenesis. These new aspects, that critically regulate angiogenesis and vascular homeostasis in health and diseased, represent unforeseen new ground to develop anti-angiogenic therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 33% |
United States | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 33% |
Scientists | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Sweden | 1 | 1% |
Portugal | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 88 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 25% |
Student > Master | 15 | 16% |
Researcher | 13 | 14% |
Student > Bachelor | 8 | 9% |
Unspecified | 3 | 3% |
Other | 9 | 10% |
Unknown | 21 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 24 | 26% |
Agricultural and Biological Sciences | 16 | 17% |
Medicine and Dentistry | 9 | 10% |
Engineering | 5 | 5% |
Unspecified | 3 | 3% |
Other | 7 | 8% |
Unknown | 28 | 30% |