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Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema

Overview of attention for article published in Frontiers in Physiology, August 2016
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Title
Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema
Published in
Frontiers in Physiology, August 2016
DOI 10.3389/fphys.2016.00329
Pubmed ID
Authors

Isabela Henriques, Miquéias Lopes-Pacheco, Gisele A. Padilha, Patrícia S. Marques, Raquel F. Magalhães, Mariana A. Antunes, Marcelo M. Morales, Nazareth N. Rocha, Pedro L. Silva, Débora G. Xisto, Patricia R. M. Rocco

Abstract

We investigated the therapeutic effects of aerobic training on lung mechanics, inflammation, morphometry and biological markers associated with inflammation, and endothelial cell damage, as well as cardiac function in a model of elastase-induced emphysema. Eighty-four BALB/c mice were randomly allocated to receive saline (control, C) or 0.1 IU porcine pancreatic elastase (emphysema, ELA) intratracheally once weekly for 4 weeks. After the end of administration period, once cardiorespiratory impairment associated with emphysema was confirmed, each group was further randomized into sedentary (S) and trained (T) subgroups. Trained mice ran on a motorized treadmill, at moderate intensity, 30 min/day, 3 times/week for 4 weeks. Four weeks after the first instillation, ELA animals, compared to C, showed: (1) reduced static lung elastance (Est,L) and levels of vascular endothelial growth factor (VEGF) in lung tissue, (2) increased elastic and collagen fiber content, dynamic elastance (E, in vitro), alveolar hyperinflation, and levels of interleukin-1β and tumor necrosis factor (TNF)-α, and (3) increased right ventricular diastolic area (RVA). Four weeks after aerobic training, ELA-T group, compared to ELA-S, was associated with reduced lung hyperinflation, elastic and collagen fiber content, TNF-α levels, and RVA, as well as increased Est,L, E, and levels of VEGF. Four weeks of regular and moderate intensity aerobic training modulated lung inflammation and remodeling, thus improving pulmonary function, and reduced RVA and pulmonary arterial hypertension in this animal model of elastase-induced emphysema.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 8 17%
Student > Bachelor 6 13%
Student > Master 5 11%
Student > Doctoral Student 4 9%
Other 4 9%
Unknown 10 22%
Readers by discipline Count As %
Medicine and Dentistry 11 24%
Agricultural and Biological Sciences 5 11%
Sports and Recreations 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Engineering 3 7%
Other 5 11%
Unknown 13 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2016.
All research outputs
#15,380,722
of 22,881,964 outputs
Outputs from Frontiers in Physiology
#6,701
of 13,671 outputs
Outputs of similar age
#238,141
of 367,231 outputs
Outputs of similar age from Frontiers in Physiology
#76
of 165 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,671 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,231 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.