Title |
The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future
|
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Published in |
Frontiers in Physiology, December 2016
|
DOI | 10.3389/fphys.2016.00563 |
Pubmed ID | |
Authors |
Arthur D. Conigrave |
Abstract |
Parathyroid hormone (PTH) defends the extracellular fluid from hypocalcemia and has powerful and well-documented actions on the skeleton and renal tubular system. To achieve a satisfactory stable plasma calcium level, the secretion of PTH, and the resulting serum PTH level, is titrated carefully to the prevailing plasma ionized Ca(2+) concentration via a Ca(2+) sensing mechanism that mediates feedback inhibition of PTH secretion. Herein, I consider the properties of the parathyroid Ca(2+) sensing mechanism, the identity of the Ca(2+) sensor, the intracellular biochemical mechanisms that it controls, the manner of its integration with other components of the PTH secretion control mechanism, and its modulation by other nutrients. Together the well-established, recently elucidated, and yet-to-be discovered elements of the story constitute the past, present, and future of the parathyroid and its calcium-sensing receptor (CaSR). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 25% |
Netherlands | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 87 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 21% |
Researcher | 11 | 13% |
Student > Bachelor | 9 | 10% |
Student > Master | 7 | 8% |
Other | 6 | 7% |
Other | 12 | 14% |
Unknown | 24 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 26% |
Biochemistry, Genetics and Molecular Biology | 20 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Agricultural and Biological Sciences | 4 | 5% |
Nursing and Health Professions | 1 | 1% |
Other | 5 | 6% |
Unknown | 28 | 32% |