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A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing

Overview of attention for article published in Frontiers in Physiology, January 2017
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing
Published in
Frontiers in Physiology, January 2017
DOI 10.3389/fphys.2016.00678
Pubmed ID
Authors

Vaida Glatt, Christopher H. Evans, Kevin Tetsworth

Abstract

In order to achieve consistent and predictable fracture healing, a broad spectrum of growth factors are required to interact with one another in a highly organized response. Critically important, the mechanical environment around the fracture site will significantly influence the way bone heals, or if it heals at all. The role of the various biological factors, the timing, and spatial relationship of their introduction, and how the mechanical environment orchestrates this activity, are all crucial aspects to consider. This review will synthesize decades of work and the acquired knowledge that has been used to develop new treatments and technologies for the regeneration and healing of bone. Moreover, it will discuss the current state of the art in experimental and clinical studies concerning the application of these mechano-biological principles to enhance bone healing, by controlling the mechanical environment under which bone regeneration takes place. This includes everything from the basic principles of fracture healing, to the influence of mechanical forces on bone regeneration, and how this knowledge has influenced current clinical practice. Finally, it will examine the efforts now being made for the integration of this research together with the findings of complementary studies in biology, tissue engineering, and regenerative medicine. By bringing together these diverse disciplines in a cohesive manner, the potential exists to enhance fracture healing and ultimately improve clinical outcomes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 <1%
Unknown 202 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 17%
Researcher 27 13%
Student > Master 21 10%
Student > Postgraduate 19 9%
Student > Bachelor 12 6%
Other 37 18%
Unknown 52 26%
Readers by discipline Count As %
Medicine and Dentistry 53 26%
Engineering 51 25%
Agricultural and Biological Sciences 10 5%
Veterinary Science and Veterinary Medicine 5 2%
Materials Science 5 2%
Other 20 10%
Unknown 59 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2017.
All research outputs
#14,042,019
of 22,947,506 outputs
Outputs from Frontiers in Physiology
#4,931
of 13,711 outputs
Outputs of similar age
#221,990
of 419,047 outputs
Outputs of similar age from Frontiers in Physiology
#102
of 227 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,711 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,047 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 227 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.