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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prostaglandin E2 As a Modulator of Viral Infections
|
|---|---|
| Published in |
Frontiers in Physiology, February 2017
|
| DOI | 10.3389/fphys.2017.00089 |
| Pubmed ID | |
| Authors |
Willem J. Sander, Hester G. O'Neill, Carolina H. Pohl |
| Abstract |
Viral infections are a major cause of infectious diseases worldwide. Inflammation and the immune system are the major host defenses against these viral infection. Prostaglandin E2 (PGE2), an eicosanoid generated by cyclooxygenases, has been shown to modulate inflammation and the immune system by regulating the expression/concentration of cytokines. The effect of PGE2 on viral infection and replication is cell type- and virus-family-dependent. The host immune system can be modulated by PGE2, with regards to immunosuppression, inhibition of nitrogen oxide (NO) production, inhibition of interferon (IFN) and apoptotic pathways, and inhibition of viral receptor expression. Furthermore, PGE2 can play a role in viral infection directly by increasing the production and release of virions, inhibiting viral binding and replication, and/or stimulating viral gene expression. PGE2 may also have a regulatory role in the induction of autoimmunity and in signaling via Toll-like receptors. In this review the known effects of PGE2 on the pathogenesis of various infections caused by herpes simplex virus, rotavirus, influenza A virus and human immunodeficiency virus as well the therapeutic potential of PGE2 are discussed. |
X Demographics
The data shown below were collected from the profiles of 78 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 18 | 23% |
| United States | 3 | 4% |
| Saint Barthélemy | 1 | 1% |
| France | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 54 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 77 | 99% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 142 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 19% |
| Student > Ph. D. Student | 21 | 15% |
| Researcher | 19 | 13% |
| Student > Postgraduate | 12 | 8% |
| Student > Master | 12 | 8% |
| Other | 20 | 14% |
| Unknown | 31 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 18% |
| Immunology and Microbiology | 19 | 13% |
| Agricultural and Biological Sciences | 18 | 13% |
| Medicine and Dentistry | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Other | 21 | 15% |
| Unknown | 39 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2023.
All research outputs
#916,372
of 25,629,945 outputs
Outputs from Frontiers in Physiology
#505
of 15,710 outputs
Outputs of similar age
#20,553
of 435,235 outputs
Outputs of similar age from Frontiers in Physiology
#12
of 233 outputs
Altmetric has tracked 25,629,945 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,710 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 435,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.