Title |
The Potential for Circulating Tumor Cells in Pancreatic Cancer Management
|
---|---|
Published in |
Frontiers in Physiology, June 2017
|
DOI | 10.3389/fphys.2017.00381 |
Pubmed ID | |
Authors |
Michael Pimienta, Mouad Edderkaoui, Ruoxiang Wang, Stephen Pandol |
Abstract |
Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit. Though much effort has gone into finding new ways for early diagnosis and treatment, average patient survival has only been improved in the order of months. Circulating tumor cells (CTCs) are shed from primary tumors, including pre-malignant phases. These cells possess information about the genomic characteristics of their tumor source in situ, and their detection and characterization holds potential in early cancer diagnosis, prognosis, and treatment. Liquid Biopsies present an alternative to tumor biopsy that are hard to sample. Below we summarize current methods of CTC detection, the current literature on CTCs in pancreatic cancer, and future perspectives. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 14% |
Researcher | 8 | 12% |
Student > Bachelor | 8 | 12% |
Student > Doctoral Student | 6 | 9% |
Student > Postgraduate | 4 | 6% |
Other | 12 | 18% |
Unknown | 18 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 31% |
Biochemistry, Genetics and Molecular Biology | 10 | 15% |
Engineering | 3 | 5% |
Agricultural and Biological Sciences | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 8 | 12% |
Unknown | 20 | 31% |