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Longitudinal Associations of Leptin and Adiponectin with Heart Rate Variability in Children

Overview of attention for article published in Frontiers in Physiology, July 2017
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Longitudinal Associations of Leptin and Adiponectin with Heart Rate Variability in Children
Published in
Frontiers in Physiology, July 2017
DOI 10.3389/fphys.2017.00498
Pubmed ID
Authors

Roos Van De Wielle, Nathalie Michels

Abstract

For early prevention of cardiovascular disease, early detection and risk factor insights are necessary. The autonomic balance reflects cardiovascular risk and can be measured by heart rate variability (HRV). Therefore, our purpose is to examine associations between HRV and the energy-related biomarkers leptin and adiponectin in children. Participants of this study were Belgian children recruited for the longitudinal ChiBS study (year 2010-2012). HRV was measured and fasting blood samples were taken in 249 children at baseline (4.4-11.0 y) and 223 children at follow-up (6.7-12.2 y). Cross-sectional and longitudinal linear regression analyses were separated by sex and adjusted for age, socio-economic status, body fat%, negative emotions, puberty, and mean heart rate. Leptin was a negative cross-sectional and longitudinal predictor of parasympathetic activity in boys; while leptin in girls was cross-sectionally associated with higher LF and LF/HF suggesting sympathetic predominance. Adiponectin was a negative cross-sectional and longitudinal predictor of parasympathetic activity in boys; but when adjusting for mean heart rate, this effect disappeared and adiponectin was a positive cross-sectional and longitudinal predictor of parasympathetic activity in girls. These results stress the importance of considering sex differences and adjustment for heart rate in testing HRV predictors. Leptin seemed disadvantageous for the autonomic balance, while adiponectin seemed advantageous for the autonomic balance in girls only. More research is needed to see whether leptin and adiponectin are interesting in cardiovascular screening/prevention or in determining the cardiovascular gain during weight loss follow-up.

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The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 14%
Student > Bachelor 6 14%
Student > Doctoral Student 5 12%
Other 4 10%
Professor 3 7%
Other 8 19%
Unknown 10 24%
Readers by discipline Count As %
Medicine and Dentistry 10 24%
Sports and Recreations 4 10%
Nursing and Health Professions 3 7%
Psychology 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 5 12%
Unknown 15 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2019.
All research outputs
#12,753,268
of 22,988,380 outputs
Outputs from Frontiers in Physiology
#3,879
of 13,736 outputs
Outputs of similar age
#143,076
of 312,615 outputs
Outputs of similar age from Frontiers in Physiology
#94
of 273 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,736 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,615 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 273 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.