Title |
Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective
|
---|---|
Published in |
Frontiers in Physiology, February 2018
|
DOI | 10.3389/fphys.2018.00127 |
Pubmed ID | |
Authors |
Joanne J. A. van Bavel, Marc A. Vos, Marcel A. G. van der Heyden |
Abstract |
Degradation of cellular material by lysosomes is known as autophagy, and its main function is to maintain cellular homeostasis for growth, proliferation and survival of the cell. In recent years, research has focused on the characterization of autophagy pathways. Targeting of autophagy mediators has been described predominantly in cancer treatment, but also in neurological and cardiovascular diseases. Although the number of studies is still limited, there are indications that activity of autophagy pathways increases under arrhythmic conditions. Moreover, an increasing number of antiarrhythmic and non-cardiac drugs are found to affect autophagy pathways. We, therefore, suggest that future work should recognize the largely unaddressed effects of antiarrhythmic agents and other classes of drugs on autophagy pathway activation and inhibition. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 17% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Student > Bachelor | 3 | 10% |
Other | 2 | 7% |
Other | 2 | 7% |
Unknown | 10 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Agricultural and Biological Sciences | 3 | 10% |
Medicine and Dentistry | 3 | 10% |
Computer Science | 1 | 3% |
Other | 3 | 10% |
Unknown | 11 | 37% |